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Saint Pantaenus (d. ca. 200) was a Christian theologian who founded the Catechetical School of Alexandria about AD 190. This school was the earliest catechetical school, and became influential in the development of Christian theology.

Pantaenus was a Stoic philosopher teaching in Alexandria. He converted to the Christian faith, and sought to reconcile his new faith with Greek philosophy. His most famous student, Clement, who was his successor as head of the Catechetical School, described Pantaenus as ''the Sicilian bee''. Although no writings by Pantaenus are extent, his legacy is known by the influence of the Catechetical School on the development of Christian theology, in particular in the early debates on the interpretation of the Bible, the Trinity, and Christology. He was the main supporter of Serapion of Antioch for acting against the influence of Gnosticism. Generally says Serapion of Antioch appointed him as a missionary of India.

In addition to his work as a teacher, according to Eusebius of Caesarea, Pantaenus Both Eusebius and Saint Jerome reported that Pantaenus found the Gospel of Matthew in Hebrew, reported to have left there in India by Saint Bartholomew. Some writers have suggested that having difficulty with the language of Saint Thomas Christians, Pantaenus misinterpreted their reference to Mar Thoma ( Bishop Thomas) as Bar Tolmai (the Hebrew name of Bartholomew). Some others say Eusebius and Saint Jerome confused India with Arabia or Persia as was done by some other classical writers.

His feast day is July 7 (June 22 in the Coptic tradition).